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Can I read Structure–activity Relationships of 3,5-Disubstituted Benzamides as Glucokinase Activators with Potent in Vivo Efficacy on EtoBox?
Structure–activity Relationships of 3,5-Disubstituted Benzamides as Glucokinase Activators with Potent in Vivo Efficacy by Tomoharu Iino; Noriaki Hashimoto; Kaori Sasaki; Sumika Ohyama; Riki Yoshimoto; Hideka Hosaka; Takuro Hasegawa; Masato Chiba; Yasufumi Nagata; Jun-ichi Eiki; Teruyuki Nishimura is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Structure–activity Relationships of 3,5-Disubstituted Benzamides as Glucokinase Activators with Potent in Vivo Efficacy about?
The optimization of our lead GK activator 2a to 3-[(1S)-2-hydroxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide (6g), a potent GK activator with good oral availability, is described, including to uncouple the relationship between potency and hydrophobicity. Following oral administration, this compound exhibited robust glucose lowering in diabetic model rodents.
Who reads Structure–activity Relationships of 3,5-Disubstituted Benzamides as Glucokinase Activators with Potent in Vivo Efficacy?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Tomoharu Iino; Noriaki Hashimoto; Kaori Sasaki; Sumika Ohyama; Riki Yoshimoto; Hideka Hosaka; Takuro Hasegawa; Masato Chiba; Yasufumi Nagata; Jun-ichi Eiki; Teruyuki Nishimura
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)