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Air Pollution Associated with Incidence and Progression Trajectory of Chronic Lung Diseases: a Population-based Cohort Study by Xiaojie Wang; Lan Chen; Miao Cai; Fei Tian; Hongtao Zou; Zhengmin (Min) Qian; Zilong Zhang; Haitao Li; Chongjian Wang; Steven W Howard; Yang Peng; Li’e Zhang; Elizabeth Bingheim; Hualiang Lin; Yunfeng Zou is a Medicine article available to read on EtoBox.

What is Air Pollution Associated with Incidence and Progression Trajectory of Chronic Lung Diseases: a Population-based Cohort Study about?

Background No prior study has examined the effects of air pollution on the progression from healthy to chronic lung disease, subsequent chronic lung multimorbidity and further to death. Methods We used data from the UK Biobank of 265 506 adults free of chronic lung disease at recruitment. Chronic lung multimorbidity was defined as the coexistence of at least two chronic lung diseases, including asthma, chronic obstructive pulmonary disease and lung cancer. The concentrations of air pollutants were estimated using land-use regression models. Multistate models were applied to assess the effect of air pollution on the progression of chronic lung multimorbidity. Results During a median follow-up of 11.9 years, 13 863 participants developed at least one chronic lung disease, 1055 developed chronic lung multimorbidity and 12 772 died. We observed differential associations of air pollution with different trajectories of chronic lung multimorbidity. Fine particulate matter showed the strongest association with all five transitions, with HRs (95% CI) per 5 μg/m 3 increase of 1.31 (1.22 to 1.42) and 1.27 (1.01 to 1.57) for transitions from healthy to incident chronic lung disease and from in

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Author

Xiaojie Wang; Lan Chen; Miao Cai; Fei Tian; Hongtao Zou; Zhengmin (Min) Qian; Zilong Zhang; Haitao Li; Chongjian Wang; Steven W Howard; Yang Peng; Li’e Zhang; Elizabeth Bingheim; Hualiang Lin; Yunfeng Zou

Publisher

BMJ

Published

2023

Language

EN

Field

Medicine (Health Sciences)