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Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors by Zhe Jin; Yulan Cheng; Alexandru Olaru; Takatsugu Kan; Jian Yang; Bogdan Paun; Tetsuo Ito; James P. Hamilton; Stefan David; Rachana Agarwal; Florin M. Selaru; Fumiaki Sato; John M. Abraham; David G. Beer; Yuriko Mori; Yutaka Shimada; Stephen J. Meltzer is a Medicine article available to read on EtoBox.

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## Abstract Although the __CDH13__ gene has been shown to undergo epigenetic silencing by promoter methylation in many types of tumors, hypermethylation of this gene in Barrett's‐associated esophageal adenocarcinogenesis has not been studied. Two hundred fifty‐nine human esophageal tissues were therefore examined for __CDH13__ promoter hypermethylation by real‐time methylation‐specific PCR. __CDH13__ hypermethylation showed discriminative receiver‐operator characteristic curve profiles, sharply demarcating esophageal adenocarcinoma (EAC) from esophageal squamous cell carcinoma (ESCC) and normal esophagus (NE) (__p__ < 0.0001). __CDH13__ normalized methylation values (NMV) were significantly higher in Barrett's esophagus (BE), dysplastic BE (D) and EAC than in NE (__p__ < 0.0000001). __CDH13__ hypermethylation frequency was 0% in NE but increased early during neoplastic progression, rising to 70% in BE, 77.5% in D and 76.1% in EAC. Both __CDH13__ hypermethylation frequency and its mean NMV were significantly higher in BE with than without accompanying EAC. In contrast, only 5 (19.2%) of 26 ESCCs exhibited __CDH13__ hypermethylation. Furthermore, both __CDH13__ hypermethylation frequ

Who reads Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors?

Author

Zhe Jin; Yulan Cheng; Alexandru Olaru; Takatsugu Kan; Jian Yang; Bogdan Paun; Tetsuo Ito; James P. Hamilton; Stefan David; Rachana Agarwal; Florin M. Selaru; Fumiaki Sato; John M. Abraham; David G. Beer; Yuriko Mori; Yutaka Shimada; Stephen J. Meltzer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2008

Language

EN

Field

Medicine (Health Sciences)