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Mathematical Models of Proprioceptors. II. Structure and Function of the Golgi Tendon Organ by Milana P. Mileusnic; Gerald E. Loeb is a Neuroscience article available to read on EtoBox.

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We developed a physiologically realistic mathematical model of the Golgi tendon organ (GTO) whose elements correspond to anatomical features of the biological receptor. The mechanical interactions of these elements enable it to capture all salient aspects of GTO afferent behavior reported in the literature. The model accurately describes the GTO's static and dynamic responses to activation of single motor units whose muscle fibers insert into the GTO, including the different static and dynamic sensitivities that exist for different types of muscle fibers (S, FR, and FF). Furthermore, it captures the phenomena of self- and cross-adaptation wherein the GTO dynamic response during motor unit activation is reduced by prior activation of the same or a different motor unit, respectively. The model demonstrates various degrees of nonlinear summation of GTO responses resulting from simultaneous activation of multiple motor units. Similarly to the biological GTO, the model suggests that the activation of every additional motor unit to already active motor units that influence the receptor will have a progressively weaker incremental effect on the GTO afferent activity. Finally, the proporti

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Author

Milana P. Mileusnic; Gerald E. Loeb

Publisher

American Physiological Society

Published

2006

Language

EN

Field

Neuroscience (Life Sciences)