About this Chemistry article
Structural Characterisation and Dehydration Behaviour of Siramesine Hydrochloride by Anne Zimmermann; Fang Tian; Heidi Lopez de Diego; Karla Frydenvang; Jukka Rantanen; Michiel Ringkjøbing Elema; Lars Hovgaard is a Chemistry article available to read on EtoBox.
In this study the crystal structures of siramesine hydrochloride anhydrate alpha-form and siramesine hydrochloride monohydrate were determined, and this structural information was used to explain the physicochemical properties of the two solid forms. In the crystal structure of the monohydrate, each water molecule is hydrogen bonded to two chloride ions, and thus the water is relatively strongly bound in the crystal. No apparent channels for dehydration were observed in the monohydrate structure, which could allow transmission of structural information during dehydration. Instead destructive dehydration occurred, where the elimination of water from the monohydrate resulted in the formation of an oily phase, which subsequently recrystallised into one or more crystalline forms. Solubility and intrinsic dissolution rate of the anhydrate alpha-form and the monohydrate in aqueous media were investigated and both were found to be lower for the monohydrate compared to the anhydrate alpha-form. Finally, the interactions between water molecules and chloride ions in the monohydrate as well as changes in packing induced by water incorporation could be detected by spectroscopic techniques.
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- Author
- Anne Zimmermann; Fang Tian; Heidi Lopez de Diego; Karla Frydenvang; Jukka Rantanen; Michiel Ringkjøbing Elema; Lars Hovgaard
- Publisher
- John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)
- Published
- 2009
- Language
- EN
- Field
- Chemistry (Physical Sciences)