About this scholarly article

101 Participation of Racial and Ethnic Minorities in Decentralized Trials: The ACTIV-6 Experience by Maximilian Rohde; Dushyantha Jayaweera; Olveen Carrasquillo; Thomas Stewart is a scholarly article available to read on EtoBox.

OBJECTIVES/GOALS: Racial and ethnic minority populations have been historically underrepresented in clinical trials, which limits the external validity of study findings. We analyze data from the ACTIV-6 trial to assess whether inclusion efforts were effective in increasing participation from minority groups. METHODS/STUDY POPULATION: ACTIV-6 is a decentralized randomized placebo-controlled platform trial investigating repurposed drugs for the treatment of mild to moderate COVID-19. Study participants could either self-refer online or be recruited through a study site. Two inclusion efforts were introduced to increase participation from racial or ethnic minority populations: targeted advertising and outreach, and strategic selection of study sites that serve diverse populations. We assessed the effectiveness of these interventions by analyzing enrollment trends over time. We also assessed whether participants from racial or ethnic minority populations experienced higher loss to follow-up. RESULTS/ANTICIPATED RESULTS: At the start of the trial, enrollment of non-Hispanic White participants outpaced enrollment from racial or ethnic minority populations. At 4 months, only 108 particip

Author

Maximilian Rohde; Dushyantha Jayaweera; Olveen Carrasquillo; Thomas Stewart

Publisher

Cambridge University Press

Language

EN