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Can I read A Strong Myelin Thickness‐axon Size Correlation Emerges in Developing Nerves Despite Independent Growth of Both Parameters on EtoBox?
A Strong Myelin Thickness‐axon Size Correlation Emerges in Developing Nerves Despite Independent Growth of Both Parameters by J. FRAHER; P. DOCKERY is a Earth and Planetary Sciences article available to read on EtoBox.
What is A Strong Myelin Thickness‐axon Size Correlation Emerges in Developing Nerves Despite Independent Growth of Both Parameters about?
The axon determines whether or not it is myelinated by the Schwann cell. At maturity there is a positive correlation between sheath thickness and axon calibre. This correlation is initially very low or absent, but gradually strengthens during development. This increase could come about because the axon continuously controls Schwann cell myelinating activity, so that a given axon calibre is associated with a particular myelin sheath thickness, an interaction which would entail the Schwann cell continuously monitoring and responding to axon size. This seems unnecessarily complex. This theoretical study shows that the strong correlation between the 2 parameters within a given myelinated fibre population may come about in a much simpler way than outlined above. This is demonstrated by modelling the growth and myelination of a hypothetical population, utilising data from earlier studies on cervical ventral motoneuron axon development. The hypothesis tested shows that the only instructive interactions by the axon on the Schwann cell necessary for the strong correlation between the 2 parameters to emerge are for the initiation of myelination, its continuation and its termination. These co
Who reads A Strong Myelin Thickness‐axon Size Correlation Emerges in Developing Nerves Despite Independent Growth of Both Parameters?
It is typically read by researchers, students, and practitioners in Earth and Planetary Sciences.
- Author
- J. FRAHER; P. DOCKERY
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0021-8782)
- Published
- 1998
- Language
- EN
- Field
- Earth and Planetary Sciences (Physical Sciences)