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PRESTO-Tango: Profiling Human GPCRome by bh is a document available to read on EtoBox.

What is PRESTO-Tango: Profiling Human GPCRome about?

The document discusses PRESTO-Tango, an open-source platform designed for the interrogation of the druggable human GPCRome using a G protein-independent β-arrestin recruitment assay. This method allows for the simultaneous profiling of nonolfactory GPCRs, including orphan receptors, to identify new ligands and therapeutic targets. The platform has been validated with over 120 nonorphan GPCR targets, demonstrating its utility in high-throughput screening and drug discovery.

Author

bh

Language

EN