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Single-dose versus multiple instillations of epirubicin as prophylaxis for recurrence after transurethral resection of pTa and pT1 transitional-cell bladder tumours: a prospective, randomized controlled study by B. ALI-EL-DEIN; A. NABEEH; M. EL-BAZ; S. SHAMAA; A. ASHAMALLAH is a Medicine article available to read on EtoBox.

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## Objective To compare single‐dose and multiple instillations of epirubicin in the chemoprophylaxis of superficial bladder tumours. ## Patients and methods In a prospective randomized and controlled study, 168 evaluable patients were assigned to three groups after transurethral resection of bladder tumour (TURBT) and histological confirmation of its superficial nature (pTa and pT1). The groups were comparable for tumour stage, grade and other tumour characteristics. In group 1, patients received a single dose of 50 mg epirubicin in 50 mL normal saline immediately after TURBT; group 2 received 50 mg epirubicin in 50 mL normal saline 1–2 weeks after TURBT and the instillations were repeated for 8 weeks and thereafter monthly to complete one year of treatment; group 3 (control group) received no adjuvant therapy after TURBT. The patients were assessed by cysto‐urethroscopy, urine cytology and DNA flow cytometry 8 weeks after resection and then every 3 months during the first 2 years and 6 monthly thereafter during the next 2 years. Intravenous urography was performed annually and when otherwise indicated. ## Results The recurrence rate was significantly lower in the patients treated

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Author

B. ALI-EL-DEIN; A. NABEEH; M. EL-BAZ; S. SHAMAA; A. ASHAMALLAH

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1464-4096)

Published

1997

Language

EN

Field

Medicine (Health Sciences)