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The document provides an overview of the epidemiology and pathogenesis of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disorder characterized by muscle weakness and a median survival of three to five years. It discusses the incidence, prevalence, risk factors, genetic susceptibility, and pathology associated with ALS, noting that sporadic cases account for 90-95% of instances, while familial cases make up 5-10%. The document also highlights the unknown etiology of ALS and various pro

Author

Victoria Catalina

Language

EN