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Oridonin attenuates the progression of atherosclerosis by inhibiting NLRP3 and activating Nrf2 in apolipoprotein E-deficient mice by Lei Wang; Xiaoqi Zhao; Jiawen Ding; Yutong Liu; Han Liu; Lei Zheng; Hongting Zhao; Zichen Sun; Kuanyu Li; Jing Cai; Tong Qiao is a scholarly article available to read on EtoBox.

What is Oridonin attenuates the progression of atherosclerosis by inhibiting NLRP3 and activating Nrf2 in apolipoprotein E-deficient mice about?

Oridonin, a well-known traditional Chinese herbal medicinal product isolated from __Isodon rubescens__ (Hemsl.) H.Hara, has many potential properties, including anti-inflammatory and antioxidant activities. However, there is no evidence whether oridonin have a protective effect on atherosclerosis. This study focused on the effects of oridonin on oxidative stress and inflammation generated from atherosclerosis. The therapeutic effect on atherosclerosis was evaluated by intraperitoneal injection of oridonin in a high-fat fed __ApoE__^__−/−__^ mouse model. We isolated mouse peritoneal macrophages and detected the effect of oridonin on oxidized low-density lipoprotein-induced lipid deposition. Oil red O staining, Masson's staining, dihydroethidium fluorescence staining, immunohistochemical staining, western blotting analysis, immunofluorescence, enzyme-linked immunosorbent assay and quantitative real-time PCR were used to evaluate the effect on atherosclerosis and explore the mechanisms. Oridonin treatment significantly alleviated the progression of atherosclerosis, reduced macrophage infiltration and stabilized plaques. Oridonin could significantly inhibit inflammation associated with

Author

Lei Wang; Xiaoqi Zhao; Jiawen Ding; Yutong Liu; Han Liu; Lei Zheng; Hongting Zhao; Zichen Sun; Kuanyu Li; Jing Cai; Tong Qiao

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN