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Intracellular Calcium Plays an Essential Role in Cardiac Development by George A. Porter Jr.; Ryan F. Makuck; Scott A. Rivkees is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Intracellular calcium signaling plays an essential role in cardiac physiology and modulates cardiac gene expression. However, the role that intracellular calcium signaling plays during cardiac development is not known. To address this issue, we examined the effects of altered intracellular calcium levels on cardiac morphogenesis. In acutely cultured mouse embryos, L‐type calcium channel blockade decreased resting intracellular calcium levels and inhibited calcium transients. Embryos cultured at embryonic day (E) 7.5–8.5 in the presence of the L‐type calcium channel blockers nifedipine and verapamil developed hearts that had a large left ventricle, lacked a right ventricle and had a long, thin outflow tract. If embryos were cultured at E7.5, calcium channel blockade also induced an abnormal, anterior cardiac loop. These alterations in development were not due to altered cardiac function, as heart rates at the end of the culture period were not affected by calcium channel blockade and blood flow was observed. Treatment with nifedipine altered the mRNA expression of the transcription factor __Gata4__, which was absent in the developing ventricles, and the sarcomeric protei

Who reads Intracellular Calcium Plays an Essential Role in Cardiac Development?

Author

George A. Porter Jr.; Ryan F. Makuck; Scott A. Rivkees

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1058-8388)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)