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Mineralocorticoid receptor antagonists in patients with acute myocardial infarction — A systematic review and meta-analysis of randomized trials by Matthias Bossard; Yasser Binbraik; Farzin Beygui; Bertram Pitt; Faiez Zannad; Gilles Montalescot; Sanjit S. Jolly is a scholarly article available to read on EtoBox.

What is Mineralocorticoid receptor antagonists in patients with acute myocardial infarction — A systematic review and meta-analysis of randomized trials about?

## Background: Although mineralocorticoid antagonists (mras) reduce mortality in patients with heart failure complicating myocardial infarction (mi), it is unclear if they could be beneficial to all patients with mi. to evaluate the utility of mras in mi patients, we performed a systematic review and meta-analysis. ## Methods: Medline, embase, and cochrane central were searched from 1965 to june 2016. conference abstracts were searched from 2000 to june 2016. randomized trials evaluating the effect of mra after mis were included. two reviewers independently extracted data and assessed study quality. data were combined using fixed-/random-effects models. ## Results: Eleven randomized clinical trials (n = 11,258) were included; 1 trial (n = 6,642) included patients with apparent heart failure (killip class iii-iv). administration of mra versus placebo or standard therapy (no-mra) after mi reduced overall and cardiovascular mortality (odds ratio [or] 0.82, 95% ci 0.73-0.93, p = .002, and or 0.82, 95% ci 0.71-0.93, p = .003, respectively; i for both = 0%). in the subgroup of trials with patients with heart failure, the mortality was 14.4% in mra group versus 16.7% in no-mra group (or 0

Author

Matthias Bossard; Yasser Binbraik; Farzin Beygui; Bertram Pitt; Faiez Zannad; Gilles Montalescot; Sanjit S. Jolly

Publisher

Elsevier BV

Published

2017

Language

EN