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Analysis of the Effects of Chitosan on Inflammation, Angiogenesis, Fibroplasia, and Collagen Deposition in Polyvinyl Alcohol Sponge Implants in Rat Wounds by Robert F. Diegelmann; James D. Dunn; William J. Lindblad; I. Kelman Cohen is a Medicine article available to read on EtoBox.

What is Analysis of the Effects of Chitosan on Inflammation, Angiogenesis, Fibroplasia, and Collagen Deposition in Polyvinyl Alcohol Sponge Implants in Rat Wounds about?

Chitosan is a large molecular weight, positively charged polysaccharide extracted and purified from the chitin of crab shells. This compound has been shown to have hemostatic activity and has been suggested for use as a topical agent in tissue repair. The objective of this study was to analyze the effect of chitosan on the wound healing response to a standardized injury in the rat. The polyvinyl alcohol sponge implant model was used as a means to deliver either chitosan or its vehicle to a standardized subcutaneous wound on the backs of Sprague‐Dawley rats. On days 8 and 14, the chitosan‐treated implants contained primarily polymorphonuclear leukocytes compared with the vehicle controls which contained mainly macrophages, fibroblasts, collagen, and new blood vessels. High‐performance liquid chromatography analysis for hydroxy‐l‐proline deposited in the sponge implants showed significantly lower amounts on both days 8 and 14 in the chitosan treatment group. These histologic and biochemical studies suggest that chitosan modulates wound healing by first reducing the influx of activated tissue macrophages, which in turn reduces the subsequent events of angiogenesis, fibroplasia, and co

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Author

Robert F. Diegelmann; James D. Dunn; William J. Lindblad; I. Kelman Cohen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1067-1927)

Published

1996

Language

EN

Field

Medicine (Health Sciences)