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The SIST software package analyzes stress-induced structural transitions in superhelical DNA, focusing on transitions to non-B form structures that can impact biological processes like replication and transcription. It utilizes a statistical mechanical model to calculate the equilibrium probabilities of various DNA conformations, including strand separation, B-Z transitions, and cruciform extrusion. The software is available for free and allows researchers to explore the competitive nature of these transiti
- Author
- Guliang Wang
- Language
- EN