Opening book details…
Can I read In Vitro Characteristics of Neonatal Hemangioma Endothelial Cells: Similarities and Differences Between Normal Neonatal and Fetal Endothelial Cells on EtoBox?
In Vitro Characteristics of Neonatal Hemangioma Endothelial Cells: Similarities and Differences Between Normal Neonatal and Fetal Endothelial Cells by Amarjit Dosanjh; James Chang; Stephen Bresnick; Lisa Zhou; John Reinisch; Michael Longaker; Marvin Karasek is a Medicine article available to read on EtoBox.
What is In Vitro Characteristics of Neonatal Hemangioma Endothelial Cells: Similarities and Differences Between Normal Neonatal and Fetal Endothelial Cells about?
**Background:** Increased angiogenesis and eventual involution are major characteristics of neonatal hemangiomas. The mechanism to explain this transition is not completely understood. **Methods:** To determine the nature of these changes, endothelial cells were isolated from eight hemangiomas and the growth characteristics and morphology of these cells were compared to cells isolated from normal fetal and neonatal skin. Three cells lines were further characterized by analyzing protein expression with immunhistochemistry and FACS analysis. **Results:** Hemangioma endothelial cells converted to a spindle‐shaped morphology similar to that of fetal endothelial cells whereas neonatal endothelial cells maintained their characteristic epithelioid morphology. While neonatal, hemangioma and fetal endothelial cells continued to express platelet‐endothelial cell adhesion molecule‐1 (PECAM‐1) and von Willebrand factor (vWf), hemangioma and fetal cells expressed both proteins at a lower level and in a distribution distinct from normal neonatal endothelial cells. Neonatal endothelial cells continued to express epithelial specific Type IV collagen, while hemangioma and fetal endothelial cells pr
Who reads In Vitro Characteristics of Neonatal Hemangioma Endothelial Cells: Similarities and Differences Between Normal Neonatal and Fetal Endothelial Cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Amarjit Dosanjh; James Chang; Stephen Bresnick; Lisa Zhou; John Reinisch; Michael Longaker; Marvin Karasek
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0303-6987)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)