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Regulation of Glycogen Synthase in Skeletal Muscle During Exercise by J. N. Nielsen; E. A. Richter is a Medicine article available to read on EtoBox.

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## Abstract Glycogen synthase (GS) catalyses the incorporation of uridine diphosphate‐glucose into glycogen in skeletal muscle. In concert with the glucose transport step, GS activity is thought to be rate‐limiting in the disposal of glucose as muscle glycogen. Glycogen synthase is regulated by both allosteric factors (primarily glucose 6‐phosphate) and covalent modification by reversible phosphorylation and dephosphorylation leading to inactivation and activation of GS, respectively. Exercise activates both stimulatory and inhibitory regulators of GS and it is thought that the resultant activity of GS during exercise depends on the relative strength of opposing signals. However, the mechanisms by which exercise regulates GS activity are not fully understood. Glycogen breakdown, the G~M~–protein phosphatase 1 complex and possibly cellular relocalization of GS may be considered important factors involved in the stimulation of GS activity during exercise, while adenosine monophosphate‐activated protein kinase and plasma adrenaline (via protein kinase A) can be considered as essential for the exercise‐induced inhibitory signals to GS.

Who reads Regulation of Glycogen Synthase in Skeletal Muscle During Exercise?

Author

J. N. Nielsen; E. A. Richter

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-6772)

Published

2003

Language

EN

Field

Medicine (Life Sciences)