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The Use of L-T4 as Liquid Solution Improves the Practicability and Individualized Dosage in Newborns and Infants with Congenital Hypothyroidism by J.H. von Heppe; H. Krude; D. L'Allemand; D. Schnabel; A. Grüters is a Medicine article available to read on EtoBox.

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Dosage recommendations for the initial therapy of congenital hypothyroidism (CH) in newborns vary between 8 μg/kg/d and 10-15 μg/kg/d. Aim: To evaluate the practicability of LT4 in liquid form and to define the initial dosage for optimal treatment. Methods: Liquid LT4 solution was administered to 28 consecutive newborns with primary CH. We measured TSH, T3, T4, free T3 and free T4 before therapy and during follow-up up to 2 years. After 2 years a standardized developmental test (Griffith) was performed. Results: The median dosage at start of therapy was 12.3 μg LTt/kg/d and decreased to about 5 μg LTt/kg/d after 9 months. The median time of normalization of TSH (<6 mU/1) was 2 weeks. In 21 patients, who received a median starting dosage of 12.7 μg LT 4 /kg (range 9.8-17.1 μg/kg), TSH levels normalized within a median of 1 week. Seven patients receiving only 10.1 μg LT»/kg normalized their TSH only after a median of 2 months. Conclusions: Newborns with CH should normalize their TSH within 1-2 weeks. The initial dose necessary to normalize TSH is not lower when a liquid solution is used. The higher dose used in tablets is not due to inefficient absorption, but rather reflects the inc

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Author

J.H. von Heppe; H. Krude; D. L'Allemand; D. Schnabel; A. Grüters

Publisher

Walter de Gruyter GmbH

Published

2004

Language

EN

Field

Medicine (Health Sciences)