Can I read Degradation Products of Proguanil — 4-Chloroaniline and Related Components with Regard to Genotoxicity on EtoBox?

Degradation Products of Proguanil — 4-Chloroaniline and Related Components with Regard to Genotoxicity by Katharina Schulz; Ulrich Oberdieck; Werner Weitschies is a Chemistry article available to read on EtoBox.

What is Degradation Products of Proguanil — 4-Chloroaniline and Related Components with Regard to Genotoxicity about?

## Abstract In the event of genotoxic impurities in drug products, knowledge of the origin and fate of these components is of particular importance. In the present study, commercially available proguanil tablets (Paludrine®) were investigated in respect of formation of the main degradation product, 4-chloroaniline (PCA), which is known to be genotoxic. The investigations made use of high performance liquid chromatography coupled with fluorescence detection (HPLC-FLD) and gas chromatography coupled with flame ionisation detection (GC-FID) systems. In addition, proposals for the structure of further proguanil degradation products were developed based on results obtained by mass spectroscopy (HPLC-MS). Database analysis using DEREK, MCASE, and Vitic was performed to obtain an initial toxicological evaluation of the proposed chemical structures. Finally, the absence of the newly established structures in stored proguanil tablets was verified.

Who reads Degradation Products of Proguanil — 4-Chloroaniline and Related Components with Regard to Genotoxicity?

Author

Katharina Schulz; Ulrich Oberdieck; Werner Weitschies

Publisher

Versita; Springer-Verlag; Springer International Publishing AG; Bratislava: Institute of Chemistry Slovak Academy of Sciences; Warszawa: Versita; Heidelberg: Springer, 2006-2014.; Bratislava: Institute of Chemistry Slovak Academy of Sciences; Berlin: De Gruyter, 2015-2016.; Bratislava: Institute of Chemistry Slovak Academy of Sciences; Heidelberg: Springer, 2017-; Bratislava: Institute of Chemistry Slovak Academy of Sciences; Warszawa: De Gruyter, 2016-2016; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0366-6352)

Published

2013

Language

EN

Field

Chemistry (Physical Sciences)