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Maturation-dependent neurotoxicity of lead acetate in vitro: Implication of glial reactions by Marie-Gabrielle Zurich; Chantra Eskes; Paul Honegger; Michèle Bérode; Florianne Monnet-Tschudi is a Neuroscience article available to read on EtoBox.
What is Maturation-dependent neurotoxicity of lead acetate in vitro: Implication of glial reactions about?
## Abstract Despite a wealth of data on the neurotoxic effects of lead at the cellular and molecular levels, the reasons for its development‐dependent neurotoxicity are still unclear. Here, the maturation‐dependent effects of lead acetate were analyzed in immature and differentiated brain cells cultured in aggregates. Markers of general cytotoxicity as well as cell‐type‐specific markers of glial and neuronal cells showed that immature brain cells were more sensitive to lead than the differentiated counterparts, demonstrating that the development‐dependent neurotoxicity of lead can be reproduced in aggregating brain cell cultures. After 10 days of treatment, astrocytes were found to be more affected by lead acetate than neurons in immature cultures, and microglial cells were strongly activated. Eleven days after cessation of the treatment, lead acetate caused a partial loss of astrocytes and an intense reactivity of the remaining ones. Furthermore, microglial cells expressed a macrophagic phenotype, and the loss of activity of neuron‐specific enzymes was aggravated. In differentiated cultures, no reactive gliosis was found. It is hypothetized that the intense glial reactions (microg
Who reads Maturation-dependent neurotoxicity of lead acetate in vitro: Implication of glial reactions?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Marie-Gabrielle Zurich; Chantra Eskes; Paul Honegger; Michèle Bérode; Florianne Monnet-Tschudi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2002
- Language
- EN
- Field
- Neuroscience (Life Sciences)