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Mortality and Apolipoprotein E in Hispanic, African-American, and Caucasian elders by Joseph H. Lee; Ming-Xin Tang; Nicole Schupf; Yaakov Stern; Diane M. Jacobs; Benjamin Tycko; Richard Mayeux is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Mortality and Apolipoprotein E in Hispanic, African-American, and Caucasian elders about?

To investigate whether mortality risk is influenced by apolipoprotein E (APOE) genotype and whether the risk differs by ethnicity, we compared the mortality risk in 2,112 individuals > or = 65 years of age residing in northern Manhattan in New York. Mortality risks associated with the APOE genotype, adjusted for sex, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides, differed significantly by ethnic group. Among Caucasian and Hispanics, the E2/E3 genotype was associated with the lowest mortality risk in the multivariate Cox proportional hazards modeling, adjusted for lipid levels, whereas mortality risk did not differ substantially between the E4/E3 and E3/E3 genotypes. Among African-Americans, the E2/E3 genotype was not associated with the lowest mortality risk, but the E4/E3 genotype was. Adjustment for heart disease, diabetes, and stroke reduced mortality risk associated with each genotype by about 50% for all ethnic groups, but the patterns remained the same. Although we cannot rule out the possibility of a healthy survival bias, our analyses designed to examine healthy survival by comparing risk of mortality in groups who were younger or older at

Who reads Mortality and Apolipoprotein E in Hispanic, African-American, and Caucasian elders?

Author

Joseph H. Lee; Ming-Xin Tang; Nicole Schupf; Yaakov Stern; Diane M. Jacobs; Benjamin Tycko; Richard Mayeux

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)