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α~2~‐Adrenoceptors are not involved in the regulation of striatal glutamate release: Comparison to dopaminergic inhibition by M.D. L. G. Harsing Jr; E. S. Vizi is a Neuroscience article available to read on EtoBox.
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## Abstract Striatal slices from the rat were loaded with [^3^H]glutamate ([^3^H]Glu) superfused measure release of radioactivity at rest and during potassium‐evoked depolarization. Addition of KC1 (22‐40 mmol/liter) to the perfusion fluid enhanced the release of tritium in a concentration‐dependent manner, and this release was abolished by omission of CaCl~2~. High‐performance liquid chromatography (HPLC) separation coupled with radiochemical delection revealed that 23% and 41% of the tritium efflux detected in the perfusion fluid under resting conditions and during potassium stimulation, respec‐lively, was due to [^3^H]Glu. At the end of the super‐fusion about 63% of residual tritium content in the tissue was [^3^H]Glu. Tritium efflux in response to KCI excess was significantly higher from striatum dissected from 6‐hydroxydopamine‐pretreated rats. Apomorphine decreased, the KCl‐evoked release of [^3^H]Glu haloperidol exerted the opposite effect, Yohimbine, which antagonized the decrease of dopa accumulation elicited by apomorphine in NSD‐1015 and γ‐butyrolactone‐pretreated rat caudate nucleus, also reversed the appmprphine inhibition of the, re‐lease of [^3^H]Glu evoked by depola
Who reads α~2~‐Adrenoceptors are not involved in the regulation of striatal glutamate release: Comparison to dopaminergic inhibition?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- M.D. L. G. Harsing Jr; E. S. Vizi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 1991
- Language
- EN
- Field
- Neuroscience (Life Sciences)