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Inhibition of Candida albicans and Staphylococcus aureus biofilms by centipede oil and linoleic acid by Kim, Yong-Guy; Lee, Jin-Hyung; Park, Jae Gyu; Lee, Jintae is a Environmental Science article available to read on EtoBox.

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Microbial biofilms are associated with persistent infections because of their high tolerance to antimicrobial agents and host defenses. The effects of centipede oil from Scolopendra subspinipes mutilans and its main components were investigated to identify non-toxic biofilm inhibitors. Centipede oil and linoleic acid at 20 mg ml À1 markedly inhibited biofilm formation by two fluconazole-resistant Candida albicans strains and three Staphylococcus aureus strains without affecting their planktonic cell growth. Also, both centipede oil and linoleic acid inhibited hyphal growth and cell aggregation by C. albicans. In addition, centipede oil and linoleic acid showed anti-biofilm activities against mixed C. albicans and S. aureus biofilms. Transcriptomic analysis showed that centipede oil and linoleic acid downregulated the expressions of several hypha/biofilm-related genes in C. albicans and a-hemolysin in S. aureus. Furthermore, both compounds effectively reduced C. albicans virulence in a nematode infection model with minimal toxicity.

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Author

Kim, Yong-Guy; Lee, Jin-Hyung; Park, Jae Gyu; Lee, Jintae

Publisher

Taylor and Francis Group; Informa UK (Taylor & Francis); Taylor & Francis; Informa UK Limited (ISSN 0892-7014)

Published

2020

Language

EN

Field

Environmental Science (Physical Sciences)