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Non‐bismuth and bismuth quadruple therapies based on previous clarithromycin exposure are as effective and safe in an area of high clarithromycin resistance: A real‐life study by Marco Romano; Antonietta Gerarda Gravina; Gerardo Nardone; Alessandro Federico; Marcello Dallio; Marco Martorano; Caterina Mucherino; Alessandra Romiti; Luciana Avallone; Lucia Granata; Katerina Priadko; Debora Compare; Concetta Tuccillo; Maria Raffaella Romito; Dolores Sgambato; Agnese Miranda; Lorenzo Romano; Carmelina Loguercio; Franco Bazzoli; Rocco Maurizio Zagari is a Medicine article available to read on EtoBox.

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## Background: Bismuth quadruple (bqt) and non-bismuth quadruple (n-bqt) therapies are the recommended first-line treatments for helicobacter (h.) pylori infection. ## Objective: To compare the efficacy of bqt and n-bqt in clinical practice in an area with high clarithromycin resistance, choosing the regimen on the basis of previous exposure to clarithromycin. ## Methods: A total of 404 consecutive h pylori-positive, naïve patients were enrolled. a total of 203 patients without previous exposure to clarithromycin received n-bqt, 100 patients for 10 days and 103 for 14 days, whereas 201 with previous exposure to clarithromycin received 10-day bqt. efficacy and treatment-related adverse events were assessed. ## Results and conclusions: Eradication rates by intention-to-treat analysis were 88.2% for n-bqt and 91.5% for bqt (p = .26); per-protocol analysis eradication rates were 91.2% and 95.8% for n-bqt and bqt, respectively (p = .07). eradication rates were significantly higher with 14-day than 10-day ct (p < .003). almost all patients had a good compliance with both n-bqt (95.6%) and bqt (95%). adverse events occurred in 24.1% and 26.9% (p = .53) of patients in the n-bqt and bqt gro

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Author

Marco Romano; Antonietta Gerarda Gravina; Gerardo Nardone; Alessandro Federico; Marcello Dallio; Marco Martorano; Caterina Mucherino; Alessandra Romiti; Luciana Avallone; Lucia Granata; Katerina Priadko; Debora Compare; Concetta Tuccillo; Maria Raffaella Romito; Dolores Sgambato; Agnese Miranda; Lorenzo Romano; Carmelina Loguercio; Franco Bazzoli; Rocco Maurizio Zagari

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1083-4389)

Published

2020

Language

EN

Field

Medicine (Health Sciences)