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Expression of c-myc Oncogens Product and ras Family Oncogene Products in Various Human Malignant Lymphomas Defined by Immunohistochemical Techniques by Shóko Mitani; Isamu Sugawara; Hiroshi Shiku; Shigeo Mori is a scholarly article available to read on EtoBox.

What is Expression of c-myc Oncogens Product and ras Family Oncogene Products in Various Human Malignant Lymphomas Defined by Immunohistochemical Techniques about?

The authors studied the expression of c-myc and ras family oncogene products in 43 cases of malignant lymphoma (ML) using the immunoperoxidase method. Unfixed frozen sections of lymph nodes from four patients with Hodgkin's disease and 39 with non-Hodgkin's lymphoma, together with normal lymph nodes, were studied by the avidin-biotin-peroxidase complex (ABC) technique. Two monoclonal antibodies, MYC-2 raised against recombinant human c-myc protein (reacting specifically with the c-myc products P62 and P67) and RASK-4 (raised against recombinant P21 and reacting specifically with ras-family product P21) were used. The c-myc product was detected in nuclei of ML cells and some normal, mainly germinal center, lymphocytes. When the staining intensity shown by normal germinal-center lymphocytes was graded as positive (+) or weakly positive (+/-), a very intensely positive reaction ( to ++) was observed in 37 cases (86%) of ML, a positive reaction (+) in four cases (9.3%), and a weakly positive reaction (+/-) in two cases (4.7%). The ras family oncogene product reaction was intensely positive (++) in two cases (4.7%), positive (+) in 16 cases (37.2%), weakly positive (+/-) in 13 cases (30

Author

Shóko Mitani; Isamu Sugawara; Hiroshi Shiku; Shigeo Mori

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1988

Language

EN