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B-po03-029 Conventional Ablation With Half Normal Saline Is Equivalent To High Power Short Duration Ablation With Normal Saline by Benedict M. Glover; Anura Malaweera; Kathryn Lauren Hong; Thea Lee; Grace Huang; Joy Sumin Park; Eduardo Sanhueza; Maria Terricabras is a Medicine article available to read on EtoBox.

What is B-po03-029 Conventional Ablation With Half Normal Saline Is Equivalent To High Power Short Duration Ablation With Normal Saline about?

Background: Ablation of deep septal substrate with thermal energy sources conveys many challenges including inadequate lesion depth, inadvertent steam pops, and conduction system injury. Objective: Pulsed electric fields (PEF) were delivered across the interventricular septum as a preclinical proof-of-concept for transmural ablation through irreversible electroporation. Methods: In 8 healthy canine 4-week survival experiments, microsecond (n52; 75-189J/animal) or nanosecond (n56; 107-275J/animal) duration PEF were applied in a bipolar fashion between solid-tip ablation catheters positioned on either side of the septum in 2-5 separate locations. Radiofrequency (RF) control lesions were delivered for comparison at non-septal sites. Results: Nanosecond PEF did not result in sustained ventricular tachyarrhythmias or skeletal muscle stimulation as opposed to microsecond PEF. Transient complete heart block was seen in 4 after delivery at the basal septum. Of these, bundle branch block persisted in 3 animals. Two animals died due to intractable VF during the initial experiment: 1 during microsecond delivery and another during an RF lesion. At 4 weeks of survival, 36 individual well-demarc

Who reads B-po03-029 Conventional Ablation With Half Normal Saline Is Equivalent To High Power Short Duration Ablation With Normal Saline?

Author

Benedict M. Glover; Anura Malaweera; Kathryn Lauren Hong; Thea Lee; Grace Huang; Joy Sumin Park; Eduardo Sanhueza; Maria Terricabras

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)