Can I read Biomechanical and Histological Aspects of Fracture Healing, Stimulated with Osteogenic Protein-1 on EtoBox?
Biomechanical and Histological Aspects of Fracture Healing, Stimulated with Osteogenic Protein-1 by T.J Blokhuis; F.C den Boer; J.A.M Bramer; J.M.G.Th Jenner; F.C Bakker; P Patka; H.J.Th.M Haarman is a Engineering article available to read on EtoBox.
What is Biomechanical and Histological Aspects of Fracture Healing, Stimulated with Osteogenic Protein-1 about?
Fracture healing could be stimulated with osteoinductive bone morphogenetic proteins (bmp's), such as osteogenic protein-1 (OP-1), but little is known about its e!ectiveness in stimulation of fracture healing. In this study, biomechanical and histological aspects of fracture healing after an injection of OP-1 in the fracture gap were investigated. In 40 goats, a closed fracture was created in the left tibia. The fractures were stabilized with an external "xator and the animals were assigned to four di!erent groups: no injection, injection of 1 mg OP-1, injection of 1 mg OP-1 with collagenous carrier material, and injection of carrier material alone. Twenty-one animals were sacri"ced after 2 weeks and 19 after 4 weeks. Biomechanical testing was perfomed on both explanted tibiae. Four longitudinal samples of the fracture were sawn, processed for histology, and examined by two observers. Biomechanical evaluation showed a higher sti!ness and strength at 2 weeks after injection of OP-1. Histological evaluation showed normal fracture healing patterns in all animals without adverse e!ects of the given injections. These data show that fracture healing can be accelerated with a single injec
Who reads Biomechanical and Histological Aspects of Fracture Healing, Stimulated with Osteogenic Protein-1?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- T.J Blokhuis; F.C den Boer; J.A.M Bramer; J.M.G.Th Jenner; F.C Bakker; P Patka; H.J.Th.M Haarman
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)
- Published
- 2001
- Language
- EN
- Field
- Engineering (Physical Sciences)