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Can I read Morphometry of dermal collagen orientation by Fourier analysis is superior to multi-observer assessment on EtoBox?
Morphometry of dermal collagen orientation by Fourier analysis is superior to multi-observer assessment by Paul PM van Zuijlen; Henry JC de Vries; Evert N Lamme; Joris E Coppens; Jan van Marle; Robert W Kreis; Esther Middelkoop is a Medicine article available to read on EtoBox.
What is Morphometry of dermal collagen orientation by Fourier analysis is superior to multi-observer assessment about?
## Abstract In human dermis, collagen bundle architecture appears randomly organized, whereas in pathological conditions, such as scar tissue and connective tissue disorders, collagen bundle architecture is arranged in a more parallel fashion. Histological examination by one or two observers using polarized light is the most common method to determine collagen orientation. The hypothesis on which this study is based is that an objective image analysis technique, Fourier analysis, would improve the reliability (are the measurements reproducible?) and the accuracy (does the method measure what it is supposed to measure?) of collagen orientation assessment, compared with observer ratings. Fourier analysis was applied to 271 images of scar tissue and normal skin that were acquired by confocal laser‐scanning microscopy. Observers rated the same areas using polarized light as well as the confocal microscopy images. Computer images consisting of different types of ellipses were generated with a fixed orientation. Observers and Fourier analysis evaluated the images to evaluate accuracy. The inter‐observer reliability was acceptable when at least three observers rated polarized light images
Who reads Morphometry of dermal collagen orientation by Fourier analysis is superior to multi-observer assessment?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Paul PM van Zuijlen; Henry JC de Vries; Evert N Lamme; Joris E Coppens; Jan van Marle; Robert W Kreis; Esther Middelkoop
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)