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MAD-FC: A Fold Change Visualization with Readability, Proportionality, and Symmetry by Corliss, Bruce A.; Wang, Yaotian; Driscoll, Francis P.; Shakeri, Heman; Bourne, Philip E. is a scholarly article available to read on EtoBox.

What is MAD-FC: A Fold Change Visualization with Readability, Proportionality, and Symmetry about?

We propose a fold change visualization that demonstrates a combination of properties from log and linear plots of fold change. A useful fold change visualization can exhibit: (1) readability, where fold change values are recoverable from datapoint position; (2) proportionality, where fold change values of the same direction are proportionally distant from the point of no change; (3) symmetry, where positive and negative fold changes are equidistant to the point of no change; and (4) high dynamic range, where datapoint values are discernable across orders of magnitude. A linear visualization has readability and partial proportionality but lacks high dynamic range and symmetry (because negative direction fold changes are bound between [0, 1] while positive are between [1, $\infty$]). Log plots of fold change have partial readability, high dynamic range, and symmetry, but lack proportionality because of the log transform. We outline a new transform and visualization, named mirrored axis distortion of fold change (MAD-FC), that extends a linear visualization of fold change data to exhibit readability, proportionality, and symmetry (but still has the limited dynamic range of linear plot

Author

Corliss, Bruce A.; Wang, Yaotian; Driscoll, Francis P.; Shakeri, Heman; Bourne, Philip E.

Published

2023

Language

EN