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Protein Adsorption Enhances Energy Dissipation in Networks of Lysozyme Amyloid Fibrils by Maurice C. E. van Dalen; Jonathan Vaneyck; Slav A. Semerdzhiev; Marcel Karperien; Janine N. Post; Mireille M. A. E. Claessens is a Materials Science article available to read on EtoBox.

What is Protein Adsorption Enhances Energy Dissipation in Networks of Lysozyme Amyloid Fibrils about?

Hydrogels of amyloid fibrils are a versatile biomaterial for tissue engineering and other biomedical applications. Their suitability for these applications has been partly ascribed to their excellent and potentially engineerable rheological properties. However, while in biomedical applications the gels have to function in compositionally complex physiological solutions, their rheological behavior is typically only characterized in simple buffers. Here we show that the viscoelastic response of networks of amyloid fibrils of the protein lysozyme in biologically relevant solutions substantially differs from the response in simple buffers. We observe enhanced energy dissipation in both cell culture medium and synovial fluid. We attribute this energy dissipation to interactions of the amyloid fibrils with other molecules in these solutions and especially to the adsorption of the abundantly present protein serum albumin. This finding provides the basis for a better understanding of the performance of amyloid hydrogels in biomedical applications.

Who reads Protein Adsorption Enhances Energy Dissipation in Networks of Lysozyme Amyloid Fibrils?

Author

Maurice C. E. van Dalen; Jonathan Vaneyck; Slav A. Semerdzhiev; Marcel Karperien; Janine N. Post; Mireille M. A. E. Claessens

Publisher

American Chemical Society (ACS)

Published

2021

Language

EN

Field

Materials Science (Physical Sciences)