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The intercellular adhesion molecule type-1 is required for rapid activation of T helper type 1 lymphocytes that control early acute phase of genital chlamydial infection in mice by J. U. Igietseme; G. A. Ananaba; J. Bolier; S. Bowers; T. Moore; T. Belay; D. Lyn; C. M. Black is a Immunology and Microbiology article available to read on EtoBox.
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## Summary Recent studies in animal models of genital chlamydial disease revealed that early recruitment of dendritic cells and specific T helper type‐1 (Th1) cells into the genital mucosae is crucial for reducing the severity of the acute phase of a cervico‐vaginal infection and arresting ascending disease. These immune effectors are therefore important for preventing major complications of genital chlamydial infection. Other __in vitro__ studies showed that intercellular adhesion molecule‐1 (ICAM‐1) plays a role in the antichlamydial action of specific CD4^+^ and CD8^+^ T cells. In the present study, we investigated the clinicopathological consequences of ICAM‐1 deficiency during chlamydial genital infection in ICAM‐1 knockout (ICAM‐1KO) mice, and analysed the cellular and molecular immunological bases for any observed pathology or complication. Following a primary genital infection of female ICAM‐l^–/–^ and ICAM‐1^+/+^ mice, the intensity of the disease during the first 3 weeks (as assessed by shedding of chlamydiae in the genital tract) was significantly greater in ICAM‐1KO mice than in ICAM‐1^+/+^ mice (__P <__ 0·0001), although both ICAM‐l^–/–^ and ICAM‐1^+/+^ mice subsequent
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It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- J. U. Igietseme; G. A. Ananaba; J. Bolier; S. Bowers; T. Moore; T. Belay; D. Lyn; C. M. Black
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)
- Published
- 1999
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)