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Platypus Globin Genes and Flanking Loci Suggest a New Insertional Model for Beta-globin Evolution in Birds and Mammals by Vidushi S Patel; Steven JB Cooper; Janine E Deakin; Bob Fulton; Tina Graves; Wesley C Warren; Richard K Wilson; Jennifer AM Graves is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Platypus Globin Genes and Flanking Loci Suggest a New Insertional Model for Beta-globin Evolution in Birds and Mammals about?
## Background Vertebrate alpha (α)- and beta (β)-globin gene families exemplify the way in which genomes evolve to produce functional complexity. From tandem duplication of a single globin locus, the α- and β-globin clusters expanded, and then were separated onto different chromosomes. The previous finding of a fossil β-globin gene (ω) in the marsupial α-cluster, however, suggested that duplication of the α-β cluster onto two chromosomes, followed by lineage-specific gene loss and duplication, produced paralogous α- and β-globin clusters in birds and mammals. Here we analyse genomic data from an egg-laying monotreme mammal, the platypus (__Ornithorhynchus anatinus__), to explore haemoglobin evolution at the stem of the mammalian radiation. ## Results The platypus α-globin cluster (chromosome 21) contains embryonic and adult α- globin genes, a β-like ω-globin gene, and the __GBY__ globin gene with homology to cytoglobin, arranged as 5'-ζ-ζ'-α^D^-α^3^-α^2^-α^1^-ω-__GBY__-3'. The platypus β-globin cluster (chromosome 2) contains single embryonic and adult globin genes arranged as 5'-ε-β-3'. Surprisingly, all of these globin genes were expressed in some adult tissues. Comparison of fla
Who reads Platypus Globin Genes and Flanking Loci Suggest a New Insertional Model for Beta-globin Evolution in Birds and Mammals?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Vidushi S Patel; Steven JB Cooper; Janine E Deakin; Bob Fulton; Tina Graves; Wesley C Warren; Richard K Wilson; Jennifer AM Graves
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, c2003-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Research Square (ISSN 1741-7007)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)