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Janoxepin and brevicompanine B: antiplasmodial metabolites from the fungus Aspergillus janus by Kennett Sprogøe; Søren Manniche; Thomas Ostenfeld Larsen; Carsten Christophersen is a Chemistry article available to read on EtoBox.

What is Janoxepin and brevicompanine B: antiplasmodial metabolites from the fungus Aspergillus janus about?

Two compounds janoxepin (1) and brevicompanine B (2) were isolated from the fungus Aspergillus janus and the structures elucidated by one-and two-dimensional NMR spectroscopic methods and mass spectrometry. Janoxepin is a novel oxepin derivative with a rare D-leucine incorporated. Brevicompanine B has previously only been isolated from Penicillium brevicompactum. Both compounds were tested in antimicrobial assays and found to be active against the malaria parasite Plasmodium falciparum 3D7 (IC 50 -values of 28 and 35 mg/ ml, respectively). However, no activity was observed in antifungal or antibacterial assays.

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Author

Kennett Sprogøe; Søren Manniche; Thomas Ostenfeld Larsen; Carsten Christophersen

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)

Published

2005

Language

EN

Field

Chemistry (Physical Sciences)