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What is HPV about?

This review discusses the role of matrix metalloproteinases (MMPs) in cancers caused by human papillomavirus (HPV) infection. MMPs help degrade the extracellular matrix and facilitate tumor invasion and metastasis. Certain MMPs like MMP1, MMP9 and MMP13 have been associated with prognosis in HPV-related cancers. The HPV oncoproteins E2 and E7 regulate MMP expression through signaling pathways such as AKT, MEK/ERK and AP-1. Increased MMP expression correlates with cancer progression and poor prognosis in sev

Author

arikusuma013

Language

EN