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The Clustering of Acetylcholine Receptors and Formation of Neuromuscular Junctions in Regenerating Mammalian Muscle Grafts by Dr. Mark D. Womble; Dr. B. M. Carlson is a Medicine article available to read on EtoBox.

What is The Clustering of Acetylcholine Receptors and Formation of Neuromuscular Junctions in Regenerating Mammalian Muscle Grafts about?

The present investigation was undertaken to study the relationship between acetylcholine receptor (AchR) clustering and endplate formation within regenerating skeletal muscle grafts. Silver staining of nerves was combined with rhodamine-alpha-bungarotoxin labeling of AchR clusters in heterotopic grafts of the rat soleus muscle. Two major graft procedures were used: whole muscle grafts and grafts which lacked the zone of original motor endplates (MEP-less grafts). These categories were subdivided into standard grafts, where subsequent innervation was allowed, and noninnervated grafts, which were experimentally deprived of innervation. Grafting brought about the death and removal of muscle fibers, followed by regeneration of myotubes within surviving basal lamina sheaths. A transient population of small extrajunctinal AchR clusters spontaneously appears shortly after myotube formation in all four muscle graft types. Early myotubes of whole muscle grafts (both innervated and standard grafts, prior to the time of innervation) also develop presumptive secondary synaptic clefts and large, organized aggregations of AchRs at original synaptic sites. At later times, nerves regenerating into

Who reads The Clustering of Acetylcholine Receptors and Formation of Neuromuscular Junctions in Regenerating Mammalian Muscle Grafts?

Author

Dr. Mark D. Womble; Dr. B. M. Carlson

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0002-9106)

Published

1986

Language

EN

Field

Medicine (Health Sciences)