Opening book details…
Can I read Treatment-related changes in neuroendocrine tumors as assessed by textural features derived from ^68^Ga-DOTATOC PET/MRI with simultaneous acquisition of apparent diffusion coefficient on EtoBox?
Treatment-related changes in neuroendocrine tumors as assessed by textural features derived from ^68^Ga-DOTATOC PET/MRI with simultaneous acquisition of apparent diffusion coefficient by Weber, Manuel; Kessler, Lukas; Schaarschmidt, Benedikt; Fendler, Wolfgang Peter; Lahner, Harald; Antoch, Gerald; Umutlu, Lale; Herrmann, Ken; Rischpler, Christoph is a Medicine article available to read on EtoBox.
What is Treatment-related changes in neuroendocrine tumors as assessed by textural features derived from ^68^Ga-DOTATOC PET/MRI with simultaneous acquisition of apparent diffusion coefficient about?
## Background Neuroendocrine tumors (NETs) frequently overexpress somatostatin receptors (SSTRs), which is the molecular basis for ^68^Ga-DOTATOC positron-emission tomography (PET) and radiopeptide therapy (PRRT). However, SSTR expression fluctuates and can be subject to treatment-related changes. The aim of this retrospective study was to assess, which changes in PET and apparent diffusion coefficient (ADC) occur for different treatments and if pre-therapeutic ^68^Ga-DOTATOC-PET/MRI was able to predict treatment response to PRRT. ## Methods Patients with histopathologically confirmed NET, at least one liver metastasis > 1 cm and at least two ^68^Ga-DOTATOC-PET/MRI including ADC maps were eligible. ^68^Ga-DOTATOC-PET/MRI of up to 5 liver lesions per patients was subsequently analyzed. Extracted features comprise conventional PET parameters, such as maximum and mean standardized uptake value (SUVmax and SUVmean) and ADC values. Furthermore, textural features (TFs) from both modalities were extracted. In patients with multiple ^68^Ga-DOTATOC-PET/MRI a pair of 2 scans each was analyzed separately and the parameter changes between both scans calculated. The same image analysis was perf
Who reads Treatment-related changes in neuroendocrine tumors as assessed by textural features derived from ^68^Ga-DOTATOC PET/MRI with simultaneous acquisition of apparent diffusion coefficient?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Weber, Manuel; Kessler, Lukas; Schaarschmidt, Benedikt; Fendler, Wolfgang Peter; Lahner, Harald; Antoch, Gerald; Umutlu, Lale; Herrmann, Ken; Rischpler, Christoph
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2001]-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2407)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)