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Can I read Liensinine Alleviates Mouse Intestinal Injury Induced by Sepsis Through Inhibition of Oxidative Stress, Inflammation, and Cell Apoptosis on EtoBox?
Liensinine Alleviates Mouse Intestinal Injury Induced by Sepsis Through Inhibition of Oxidative Stress, Inflammation, and Cell Apoptosis by Guanglu Wang; Fenfen Ma; Kunmei Xie; Xueqing Li; Xuelian Tan; Yan Xia; Yan Wang; Jingquan Dong is a Immunology and Microbiology article available to read on EtoBox.
What is Liensinine Alleviates Mouse Intestinal Injury Induced by Sepsis Through Inhibition of Oxidative Stress, Inflammation, and Cell Apoptosis about?
Sepsis is a clinical syndrome triggered by an imbalanced host response to pathogens that can lead to multiple organ dysfunction. The immune response and barrier function of the gut play an important role in the pathogenesis and progression of sepsis. This study aimed to explore the potential role of natural alkaloid Liensinine in the treatment of intestinal injury caused by sepsis and its possible molecular mechanism. In this study, a mouse model of sepsis was established by injecting LPS to explore the protective effect of Liensinine on intestinal injury in sepsis. The results showed that Liensinine could reduce the intestinal damage caused by LPS and increase the number of goblet cells. Furthermore, it decreased the release of inflammatory cytokines by inhibiting NF-kB phosphorylation and NLRP3 inflammasome synthesis. Liensinine also reduced the oxidative stress and ROS accumulation caused by LPS, and played an anti-oxidative stress role by regulating the Nrf2/keap1 signaling pathway. In addition, Liensinine alleviated the inhibition of intestinal autophagy caused by LPS by inhibiting the PI3K/Akt/mTOR pathway. And then it reduced the excessive apoptosis of intestinal cells. This
Who reads Liensinine Alleviates Mouse Intestinal Injury Induced by Sepsis Through Inhibition of Oxidative Stress, Inflammation, and Cell Apoptosis?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Guanglu Wang; Fenfen Ma; Kunmei Xie; Xueqing Li; Xuelian Tan; Yan Xia; Yan Wang; Jingquan Dong
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)