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Evidence of Fetal Pulmonary Aspiration of Intra-amniotic Administered Surfactant in Animal Experiment by R. Illia; C. Solana; P. Oliveri; J. Toblli; M.U. Imaz; D. Häbich is a Medicine article available to read on EtoBox.

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## Introduction: The instillation of surfactant into the airways of patients with respiratory distress syndrome (RDS), especially in the neonatal period, is a proven therapy. The preventive therapy of RDS through intra-amniotic injection of surfactant has been reported recently. It has not been conclusively shown, however, that the surfactant administered in this way actually reaches the fetal pulmonary airways. Objective: To study the distribution in fetal organs of a natural surfactant labeled with technetium-99m and injected through amniocentesis into the amniotic sac of guinea pigs in the last third of pregnancy. Methods: After stimulating fetal respiratory movements with aminophylline 0.3 ml of an aqueous suspension containing 0.75 mg of phospholipids of a natural bovine surfactant labeled with technetium-99m, together with 0.1 ml of the biological dye carmine indigo, were injected into the amniotic sac. One hour later fetuses were delivered by cesarean section. In those that were dye-stained, dosimetric and gammagraphic tests were applied to trachea, lungs, esophagus, stomach, heart, liver, kidneys and placenta. Results: Significant radio isotopic activity was found in both l

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Author

R. Illia; C. Solana; P. Oliveri; J. Toblli; M.U. Imaz; D. Häbich

Publisher

Walter de Gruyter GmbH

Published

2004

Language

EN

Field

Medicine (Health Sciences)