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Can I read Variable Diagnostic Performance of Stool Xpert in Pediatric Tuberculosis: a systematic review and meta-analysis on EtoBox?
Variable Diagnostic Performance of Stool Xpert in Pediatric Tuberculosis: a systematic review and meta-analysis by Gebre, Meseret ;Cameron, Lindsay Hatzenbuehler ;Tadesse, Getachew ;Woldeamanuel, Yohannes ;Wassie, Liya is a Medicine article available to read on EtoBox.
What is Variable Diagnostic Performance of Stool Xpert in Pediatric Tuberculosis: a systematic review and meta-analysis about?
## Abstract ## Background Difficult specimen collection and low bacillary load make microbiological confirmation of tuberculosis (TB) in children challenging. In this study, we conducted a systematic review and meta-analysis to assess the diagnostic accuracy of Xpert on stool for pediatric tuberculosis. ## Methods Our search included studies from 2011 through 2019, and specific search terms were used to retrieve articles from Pubmed, EMBASE, BIOSIS, ClinicalTrials.gov, and Google Scholar. Risk of bias was assessed using the QUADAS 2 tool. The protocol was registered in PROSPERO (CRD42018083637). Summary estimates of sensitivity and specificity were conducted using meta-disc Software assuming a random-effects model. ## Results We identified 12 eligible studies, which included data from 2177 children, of whom 295 (13.6%) had bacteriologically confirmed TB on respiratory specimens. The pooled sensitivity of Xpert MTB/RIF on stool specimens compared with bacteriologically confirmed tuberculosis with respiratory specimens was 0.50 (95% CI, 0.44–0.56) with an __I__^2^ of 86%, which was statistically significant (__P__ < .001). The pooled specificity was 0.99 (95% CI, 0.98–0.99; __I__^2^
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- Author
- Gebre, Meseret ;Cameron, Lindsay Hatzenbuehler ;Tadesse, Getachew ;Woldeamanuel, Yohannes ;Wassie, Liya
- Publisher
- Oxford University Press (OUP)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)