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Weak TCR stimulation induces a calcium signal that triggers IL-4 synthesis, stronger TCR stimulation induces MAP kinases that control IFN-γ production by Abdallah Badou; Magali Savignac; Marc Moreau; Catherine Leclerc; Gilles Foucras; George Cassar; Pierre Paulet; Dominique Lagrange; Philippe Druet; Jean-Charles Guéry; Lucette Pelletier is a Immunology and Microbiology article available to read on EtoBox.

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Th1 and Th2 cells produce different cytokines and have distinct functions. Th1/Th2 cell differentiation is influenced, among other factors, by the nature of TCR-MHC interactions. However, how the TCR transduces a signal resulting in IFN-+ or IL-4 production is a matter of debate. For example, some authors reported a loss of calcium signaling pathway in Th2 cells. We used a T cell hybridoma producing IL-4 upon weak TCR stimulation and both IL-4 and IFN-+ for strong TCR engagement as a model to study how TCR signaling pathways are differentially activated in both conditions of stimulation and how this influences the production of cytokines. We show that: (1) the calcium response is identical following weak and strong TCR stimulation; (2) mitogen-activated protein kinase (MAPK) activation is a gradual phenomenon depending upon the strength of TCR activation; (3) a calcium response, even weak, triggers IL-4 expression; (4) IFN-+ synthesis requires not only a calcium response but also MAPK activation. The MAPK pathway is dispensable for IL-4 production, although it amplifies IL-4 synthesis upon strong TCR stimulation; (5) TCR-induced IL-4 production also depends on calcium signaling in

Who reads Weak TCR stimulation induces a calcium signal that triggers IL-4 synthesis, stronger TCR stimulation induces MAP kinases that control IFN-γ production?

Author

Abdallah Badou; Magali Savignac; Marc Moreau; Catherine Leclerc; Gilles Foucras; George Cassar; Pierre Paulet; Dominique Lagrange; Philippe Druet; Jean-Charles Guéry; Lucette Pelletier

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)

Published

2001

Language

EN

Field

Immunology and Microbiology (Life Sciences)