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What is Erionite Toxicity and Macrophage Interaction about?
The study investigates the interaction between fibrous erionite and THP-1 macrophages, revealing that phagocytosis leads to a significant release of cations and hydronium ions sequestration, causing pH dysregulation. This dysregulation results in mitochondrial suffering due to the hyperactivation of ATP-dependent proton pumps, which may contribute to chronic inflammation and cancer development. The findings highlight the toxicological mechanisms of erionite, which is classified as a Group 1 human carcinogen
- Author
- unnoted
- Language
- EN