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Mussel-mimetic Tissue Adhesive for Fetal Membrane Repair: a Standardized Ex Vivo Evaluation Using Elastomeric Membranes by C. M. Haller; W. Buerzle; C. E. Brubaker; P. B. Messersmith; E. Mazza; N. Ochsenbein-Koelble; R. Zimmermann; M. Ehrbar is a Medicine article available to read on EtoBox.

What is Mussel-mimetic Tissue Adhesive for Fetal Membrane Repair: a Standardized Ex Vivo Evaluation Using Elastomeric Membranes about?

## Abstract ## Objective Iatrogenic preterm premature rupture of membranes (iPPROM), the main complication of invasive interventions in the prenatal period, seriously limits the benefit of diagnostic or surgical prenatal procedures. This study aimed to evaluate preventive plugging of punctured fetal membranes in an __ex vivo__ situation using a new mussel‐mimetic tissue adhesive (mussel glue) to inhibit leakage. ## Methods A novel biomechanical test device that tests the closure of injured membranes under near‐physiological conditions was used. Mussel glue, a poly(ethylene glycol)‐based hydrogel, was used to seal membrane defects of up to 3 mm in mechanically well‐defined elastomeric membranes with three different degrees of stiffness. ## Results Elastomeric test membranes were successfully employed for testing mussel glue under well‐defined conditions. Mussel glue plugs were distended by up to 94%, which translated to an improved sealing efficiency on elastomeric membranes with high stiffness. For the stiffest membrane tested, a critical burst pressure of 48 mbar (36 mmHg) was accomplished in this __ex vivo__ setting. ## Conclusions Mussel glue appears to efficiently seal membrane

Who reads Mussel-mimetic Tissue Adhesive for Fetal Membrane Repair: a Standardized Ex Vivo Evaluation Using Elastomeric Membranes?

Author

C. M. Haller; W. Buerzle; C. E. Brubaker; P. B. Messersmith; E. Mazza; N. Ochsenbein-Koelble; R. Zimmermann; M. Ehrbar

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0197-3851)

Published

2011

Language

EN

Field

Medicine (Health Sciences)