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Integrated Genomic Analyses of Hepatocellular Carcinoma by Ya-Sian Chang; Siang-Jyun Tu; Hong-Da Chen; Ming-Hon Hsu; Yu-Chia Chen; Dy-San Chao; Chin-Chun Chung; Yu-Pao Chou; Chieh-Min Chang; Ya-Ting Lee; Ju-Chen Yen; Long-Bin Jeng; Jan-Gowth Chang is a Medicine article available to read on EtoBox.

What is Integrated Genomic Analyses of Hepatocellular Carcinoma about?

Background Genomic alterations play important roles in the development of cancer. We explored the impact of proteincoding genes and transcriptomic changes on clinical and molecular alterations in Taiwanese hepatocellular carcinoma (HCC) patients. Methods We analyzed 147 whole-exome sequencing and 100 RNA sequencing datasets of HCC and compared them with The Cancer Genome Atlas (TCGA)-Liver Hepatocellular Carcinoma cohort and develop a panel of 81 apoptosis-related genes for molecular classification. Results TERT (50%), TP53 (25%), CTNNB1 (14%), ARID1A (12%), and KMT2C (11%) were the most common genetic alterations of cancer-related genes. ALDH2 and KMT2C mutated at much higher frequencies in our cohort than in TCGA, whereas CTNNB1 was found only in 14% of our Taiwanese patients. A high germline mutation rate of ALDH2 in the APOBEC mutational signature and herb drug-related aristolochic acid-associated signature was also observed. Groups A and B of HCC were identified when we used apoptosis-related genes for molecular classification. The latter group, which had poorer survival outcomes, had significantly more aDC, CD4+ Tem, macrophages M2, NKT, plasma cells, and Th1 cells, and less

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Author

Ya-Sian Chang; Siang-Jyun Tu; Hong-Da Chen; Ming-Hon Hsu; Yu-Chia Chen; Dy-San Chao; Chin-Chun Chung; Yu-Pao Chou; Chieh-Min Chang; Ya-Ting Lee; Ju-Chen Yen; Long-Bin Jeng; Jan-Gowth Chang

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)