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The effect of zoledronic acid incorporated in a poly(D,L-lactide) implant coating on osteoblasts in vitro by S. Greiner; A. Kadow-Romacker; M. Lübberstedt; G. Schmidmaier; B. Wildemann is a Engineering article available to read on EtoBox.

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## Abstract Bisphosphonates such as zoledronic acid (ZOL) are used in diseases associated with osteoclast‐mediated bone loss. However, their antiresorptive activity is partly due to their effect on osteoblasts. Local application might increase the therapeutical fence and their local efficiency and reduce systemic side effects. Aim of the study was to investigate the effect of ZOL on human osteoblasts like cells __in vitro__ with special focus on the synthesis of factors mediating osteoclast differentiation (RANKL, OPG). ZOL was incorporated in an implant coating based on poly(D,L‐lactide) (PDLLA) in different concentrations (10–150 μ__M__). Control groups were treated with uncoated implants, PDLLA‐coated implants, and ZOL pure substance in corresponding concentrations. After an experimental period of 144 h, primary human osteoblasts were stained with alamar blue and cell viability was measured. Procollagen I synthesis, osteoprotegerin (OPG) secretion, and soluble receptor activator of nuclear factor‐κB ligand (sRANKL) were analyzed. Results showed that cell viability was not affected when treated with doses equivalent up to 100 μ__M__ ZOL‐coated implants (ZOL‐CI). Procollagen I syn

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Author

S. Greiner; A. Kadow-Romacker; M. Lübberstedt; G. Schmidmaier; B. Wildemann

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2006

Language

EN

Field

Engineering (Physical Sciences)