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A systematic review and meta‐analysis on oncological radiotherapy in patients with a cardiac implantable electronic device: Prevalence and predictors of device malfunction in 3121 patients by Vincenzo Livio Malavasi; Jacopo Francesco Imberti; Alberto Tosetti; Giulio Francesco Romiti; Marco Vitolo; Massimo Zecchin; Ercole Mazzeo; De Marco Giuseppina; Frank Lohr; Teresa Lopez‐Fernandez; Giuseppe Boriani is a Medicine article available to read on EtoBox.

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## Abstract ## Background The number of patients with cardiac implantable electronic devices (CIEDs) undergoing radiotherapy (RT) for cancer treatment is growing. At present, prevalence and predictors of RT‐induced CIEDs malfunctions are not defined. ## Methods Systematic review and meta‐analysis conducted following the PRISMA recommendations. PubMed, Scopus and Google Scholar were searched from inception to 31/01/2022 for studies reporting RT‐induced malfunctions in CIEDs patients. Aim was to assess the prevalence of RT‐induced CIEDs malfunctions and identify potential predictors. ## Results Thirty‐two out of 3962 records matched the inclusion criteria and were included in the meta‐analysis. A total of 135 CIEDs malfunctions were detected among 3121 patients (6.6%, 95% confidence interval [CI]: 5.1%–8.4%). The pooled prevalence increased moving from pacemaker (PM) to implantable cardioverter defibrillator (ICD), and cardiac resynchronization therapy and defibrillator (CRT‐D) groups (4.1%, 95% CI: 2.9–5.8; 8.2% 95% CI: 5.9–11.3; and 19.8%, 95% CI: 11.4–32.2 respectively). A higher risk ratio (RR) of malfunctions was found when neutron‐producing energies were used as compared to non

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Author

Vincenzo Livio Malavasi; Jacopo Francesco Imberti; Alberto Tosetti; Giulio Francesco Romiti; Marco Vitolo; Massimo Zecchin; Ercole Mazzeo; De Marco Giuseppina; Frank Lohr; Teresa Lopez‐Fernandez; Giuseppe Boriani

Publisher

John Wiley and Sons Inc.

Published

2022

Language

EN

Field

Medicine (Health Sciences)