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PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction by Takashi Oda; Young Ok Jung; Heung Soo Kim; Xiaohe Cai; Jesús M. López-Guisa; Yukiko Ikeda; Allison A. Eddy is a Medicine article available to read on EtoBox.

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## Background: Progressive renal disease is characterized by the induction of plasminogen activator inhibitor-1 (pai-1), suggesting that impaired activity of the renal plasmin cascade may play a role in renal fibrosis. ## Methods: To test this hypothesis, the severity of renal fibrosis caused by unilateral ureteral obstruction (uuo) was compared in pai-1 wild-type (+/+) and pai-1 deficient (-/-) mice. the extent of interstitial inflammation and fibrosis, renal plasminogen activator and plasmin activity, and renal expression of profibrotic genes was evaluated after 3, 7, and 14 days of uuo. ## Results: Renal pai-1 mrna levels increased 8- to 16-fold in the +/+ mice after uuo surgery, and pai-1 protein was detected in kidney homogenates. interstitial fibrosis was significantly attenuated in -/- mice compared with +/+ mice at day 7 and day 14, based on the interstitial area stained with picrosirius red and total kidney collagen content. however, neither the mean renal plasminogen activator nor plasmin activities were increased in -/- mice compared with +/+ mice. the number of interstitial macrophages were significantly lower in the -/- mice three and seven days after uuo; interstitial

Who reads PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction?

Author

Takashi Oda; Young Ok Jung; Heung Soo Kim; Xiaohe Cai; Jesús M. López-Guisa; Yukiko Ikeda; Allison A. Eddy

Publisher

Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)

Published

2001

Language

EN

Field

Medicine (Health Sciences)