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Environmental and occupational exposure to metals (manganese, mercury, iron) and Parkinson’s disease in low and middle-income countries: a narrative review by Maria Ana Gonzalez-Alvarez; David Hernandez-Bonilla; Noel Isaias Plascencia-Alvarez; Horacio Riojas-Rodriguez; Diego Rosselli is a Environmental Science article available to read on EtoBox.
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## Abstract ## Objectives We designed and conducted a narrative review consistent with the PRISMA guidelines (PROSPERO registration number: CRD42018099498) to evaluate the association between environmental metals (manganese, mercury, iron) and Parkinson’s Disease (PD) in low and middle-income countries (LMIC). ## Methods Data sources: A total of 19 databases were screened, and 2,048 references were gathered. Study selection: Randomized controlled trials, cluster trials, cohort studies, case-control studies, nested case-control studies, ecological studies, cross-sectional studies, case series, and case reports carried out in human adults of LMIC, in which the association between at least one of these three metals and the primary outcome were reported. Data extraction: We extracted qualitative and quantitative data. The primary outcome was PD cases, defined by clinical criteria. A qualitative analysis was conducted. ## Results Fourteen observational studies fulfilled the selection criteria. Considerable variation was observed between these studies’ methodologies for the measurement of metal exposure and outcome assessment. A fraction of studies suggested an association between the ex
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It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Maria Ana Gonzalez-Alvarez; David Hernandez-Bonilla; Noel Isaias Plascencia-Alvarez; Horacio Riojas-Rodriguez; Diego Rosselli
- Publisher
- Walter de Gruyter GmbH
- Published
- 2021
- Language
- EN
- Field
- Environmental Science (Physical Sciences)