About this Environmental Science article

Spermatogenesis in Aged Rats After Prenatal 3,3′,4,4′,5-Pentachlorobiphenyl Exposure by Shin Wakui; Fumio Takagi; Tomoko Muto; Kiyofumi Yokoo; Shyou Hirono; Yasuko Kobayashi; Kinji Shirota; Fumiaki Akahori; Yoshihiko Suzuki; Hiroshi Hano; Hitoshi Endou; Yoshikatsu Kanai is a Environmental Science article available to read on EtoBox.

We previously reported that prenatal exposure to 3,3 ,4,4 ,5-pentachlorobiphenyl (PCB126) had dose-related adverse effects on the spermatogenesis of 7(pubescent)-and 17(adult)-week-old rats, but the effects in middle and old age have been unclear. In this study, the spermatogenesis of male Sprague-Dawley rats whose dams had been injected (i.g.) with 25 pg, 2.5 ng, 250 ng, or 7.5 g of PCB126/kg or the vehicle on days 13-19 post-conception was investigated at 52 and 90 weeks of age. At 52 weeks, the 7.5 g group showed a significant decrease of preleptotene spermatocytes in stages VII-VIII seminiferous tubules, round spermatids increased at stages VI-VII and elongated spermatids decreased at stage VIII, while the spermatogenesis of the other PCB-treated groups were similar to that of the vehicle group. At 90 weeks, the 7.5 g group showed a significant decrease of spermatogenic cells at many stages, and the 250 ng group showed a significant decrease of preleptotene spermatocytes at stages VII-VIII, and round spermatids increased at stages VI-VII, elongated spermatids decreased at stage VIII, and the spermatogenesis of the 2.5 ng and 25 pg groups were similar to those of the vehicle gro

Author

Shin Wakui; Fumio Takagi; Tomoko Muto; Kiyofumi Yokoo; Shyou Hirono; Yasuko Kobayashi; Kinji Shirota; Fumiaki Akahori; Yoshihiko Suzuki; Hiroshi Hano; Hitoshi Endou; Yoshikatsu Kanai

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

2007

Language

EN

Field

Environmental Science (Life Sciences)