Opening book details…
Can I read Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents on EtoBox?
Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents by Meselhy R. Meselhy is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents about?
Three new (1-3) and five known compounds (4-8) were isolated from the oleogum resin of Commiphora wightii (Arnott.) Bhanol. Their structures were elucidated by spectroscopic and chemical methods. The MeOH extract and the EtOAc-sol. fraction were found to demonstrate significant inhibition of NO formation in lipopolysaccharide (LPS)-activated murine macrophages J774.1 in vitro (IC(50) values of 16.4 and 12.8 microg/ml, respectively). When compared with curcumin (IC(50) value of 12.3 microM), Z- and E-Guggulsterones (4 and 5, respectively) were the most potent inhibitors of NO production (IC(50) values of 1.1 and 3.3 microM, respectively), followed by myrrhanol A (7) and myrrhanone A (8) (IC(50) values of 21.1 and 42.3 microM, respectively). Guggulsterone-M (1) and its didehydro derivative (2) were weak inhibitors, while guggulsterols I (6) and Y (3) were inactive (IC(50) >500 microM).
Who reads Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Meselhy R. Meselhy
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0031-9422)
- Published
- 2003
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)