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Aberrant expression of muc1 mucin in ductal hyperplasia and ductal carcinoma In situ of the breast by Ellen C.M. Mommers; Angelique M. Leonhart; Silvia von Mensdorff‐Pouilly; Dick J. Schol; Jo Hilgers; Chris J.L.M. Meijer; Jan P.A. Baak; Paul J. van Diest is a Medicine article available to read on EtoBox.
What is Aberrant expression of muc1 mucin in ductal hyperplasia and ductal carcinoma In situ of the breast about?
MUC1 mucin is a high molecular weight transmembrane glycoprotein expressed on the apical cell surface of normal glandular epithelia. In many human adenocarcinomas, this protein is up-regulated and/or underglycosylated, and its expression changes from apical to the entire cell membrane. It is thought that entire cell membrane expression of MUC1 reduces cell-cell and cell-extracellular matrix interactions and therefore may facilitate invasive growth and development of metastases. In this study, we determined immunohistochemically the expression of normal and underglycosylated MUC1 in normal breast tissue (n ؍ 8) and in a spectrum of breast lesions, including usual ductal hyperplasia (n ؍ 23), atypical ductal hyperplasia (n ؍ 7), and ductal carcinoma in situ (DCIS) (n ؍ 22). We used 4 monoclonal antibodies; 115D8 is directed to a glycopeptide, the other 3 to the peptide core of the molecule, of which 139H2 is not affected by the degree of glycosylation of MUC1, whereas SM3 and VU-4-H5 stain only underglycosylated forms. All cases showed apical positivity for 115D8 and 139H2. Entire cell membrane expression of fully (normal) glycosylated MUC1 was mainly found in DCIS lesions. A
Who reads Aberrant expression of muc1 mucin in ductal hyperplasia and ductal carcinoma In situ of the breast?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ellen C.M. Mommers; Angelique M. Leonhart; Silvia von Mensdorff‐Pouilly; Dick J. Schol; Jo Hilgers; Chris J.L.M. Meijer; Jan P.A. Baak; Paul J. van Diest
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)